TUMOR CELL BIOLOGY
PROGRAM of the MEETING APRIL 11 and 12, 2005
LOCATION: De Werelt, Lunteren
| Monday | ||
| 9.00 | Registration and coffee | |
| 9.50 | Welcome (G. van Muijen) | |
| Session 1 | chairman: P. Nederlof | |
| 10.00 | J. Gibcus (Schuuring, UMCG): | |
| Characterization of the amplified region 11q13 in laryngeal cancer | ||
| 10.20 | E. van Beers (Nederlof, NKI) | |
| Discovering a-CHG profiles in familial breast cancers | ||
| 10.40 | I. Veltman (Geurts van Kessel, UMCN) | |
| Identification of recurrent chromosomal aberrations in germ cell tumors of neonates and infants using ArrayCHG | ||
| 11.00 | A. Bonné (Geurts van Kessel, UMCN) | |
| Familial renal cell cancer: high-throughput translocation breakpoint cloning using chromosome flow-sorting and ArrayCHG | ||
| 11.20 | Coffee/tea break | |
| 11.40 | Commercial presentations | |
| (Applied Biosystems, Promega Benelux, Corning BV, Snijders Scientific BV, VWR International BV, Sanbio BV, Perbio Science, Beckman Coulter, Sigma-Aldrich Chemie, Dépex BV, Tebu-bio, ITK Diagnostics BV, Westburg BV, Roche Diagnostics Nederland, BIOKÉ, Omnilabo International BV, Invitrogen, BD Biosciences Benelux, Eurogentec Nederland BV, Greiner bio-One BV, Stratagene Europe) | ||
| Session 2 | chairman: L. Dorssers | |
| 12.00 | A. Hollestelle (Schutte, EUR) | |
| Genetic versus epigenetic inactivation of E-cadherin involves two distinct biological pathways | ||
| 12.20 | J. Martens (Foekens, EUR) | |
| DNA-hypermethylation of PITX2 and risk of breast cancer recurrence in lymph node-negative hormone receptor-positive breast cancer patients | ||
| 12.40 | D. Geerts (Versteeg, AMC) | |
| Molecular wiring of the neuroblastoma cancer cell: the role of the MEIS1 homeobox gene | ||
| 13.00 | Lunch | |
| 13.30 | Meeting project leaders | |
| Session 3 | chairman: t.b.a. | |
| 14.00 | K. de Visser (Coussens, UCSF) | |
| B lymphocytes promote de novo epithelial carcinogenesis by regulating chronic inflammation | ||
| 14.20 | W. van Veelen (Höppener, UMCU) | |
| Multistep carcinogenesis in medullary thyroid carcinoma development: Involvement of the WNT signaling pathway and cell cycle regulator P18 | ||
| 14.40 | R. Groen (Spaargaren, AMC) | |
| Aberrant activation of the WNT pathway in lymphoproliferative disease by distinct mechanisms | ||
| 15.00 | J.P. ten Klooster (Hordijk, Sanquin) | |
| Targeting and activation of Rac1 are mediated by the exchange factor ß-Pix | ||
| 15.20 | Coffee/tea break; commercial presentations | |
| Session 4 | chairman: t.b.a. | |
| 16.00 | E. Boon (Van der Neut, AMC) | |
| The receptor tyrosine kinases Met and Ron are not expressed in intestinal polyps of Apc+/Min mice | ||
| 16.20 | J. Meijer (Roos, NKI) | |
| The role of chemokine receptor CXCR5 in colon carcinoma metastasis | ||
| 16.40 | J. Zeilstra (Van der Neut, AMC) | |
| Identifying CD44 related tumour suppressive pathways in intestinal cancer | ||
| 17.00 | A. Greijer (Meijer, VUMC) | |
| mTOR and HIF-1 expression in colorectal adenomas and carcinomas | ||
| 18.00 | Diner | |
| Guest-Speaker | chairman: G. van Muijen | |
| 20.00 | H. Clevers (Hubrecht laboratorium): | |
| WNT and Notch-signaling in intestinal cancer | ||
| Tuesday | ||
| 8.15 | Breakfast | |
| Session 5 | chairman: t.b.a. | |
| 9.00 | A. van der Horst (Burgering, UMCU) | |
| Usp7/HAUSP deubiquitinates mono-ubiquinated FOXO4 | ||
| 9.20 | C. Ramaekers (Wouters, UM) | |
| K63 Poly-ubiquitination protects cells against mutations induced by DNA lesion bypass polymerases | ||
| 9.40 | E. Meulmeester (Jochemsen, LUMC) | |
| Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2 | ||
| 10.00 | M. Lohrum (NCMLS) | |
| Function and regulation of p73 and p63 in p53-mediated tumour suppression | ||
| 10.20 | Coffee/tea break, Commercial presentations | |
| Session 6 | chairman: t.b.a. | |
| 11.10 | J. van Kilsdonk (Swart, RU) | |
| Activated leukocyte cell adhesion molecule (CD166/MEMD), a sensor of cell density controlling invasive growth | ||
| 11.30 | E. Danen (Sonnenberg, NKI) | |
| Integrins control motile strategy through a Rho-Cofilin pathway | ||
| 11.50 | K. Clark (Van Leeuwen, NCMLS) | |
| TRPM7 regulates cell adhesion by promoting relaxation of the actomyosin cytoskeleton | ||
| 12.10 | A. Mertens (Sonnenberg, NKI) | |
| The RAC activator Tiam 1 controls tight junction biogenesis in keratinocytes by association with the Par polarity complex | ||
| 13.00 | Lunch; commercial presentations | |
| Session 7 | chairman:L. Hameetman | |
| 13.50 | M. de Graauw (Van de Water, LACDR) | |
| Phosphotyrosine-proteomics of the epithelial mesenchymal transition | ||
| 14.10 | P. van Hennik (Hordijk, Sanquin) | |
| Role of p38 and p42/44 MAPKs in migration of hematopoietic stem and progenitor cells | ||
| 14.30 | M. Magagnin (Wouters, UM) | |
| Determination of both the mechanisms and consequences of regulating mRNA translation during hypoxia | ||
| 14.50 | Coffee/tea break; commercial presentations | |
| Session 8 | chairman: t.b.a. | |
| 15.20 | A. de Jong (Van de Sluijs, UMCU) | |
| Munc13-4 is an effector of rab27a and controls secretion of lysosomes in haematopoietic cells | ||
| 15.40 | G. Verhaegh (Schalken, UMCN) | |
| Differential expression of winged-helix/forkhead (fox) genes in human prostate carcinoma and the role of FoxL1 in prostate-specific gene expression | ||
| 16.00 | R. Roovers (Van Bergen en Henegouwen, UU) | |
| Efficient inhibition of EGFR signaling and of tumour growth by antagonistic anti-AGFR nanobodies | ||
| 16.20 | Presentation award and closure | |